Ion channel regulation of intracellular calcium and airway smooth muscle function
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چکیده
منابع مشابه
Ion channel regulation of intracellular calcium and airway smooth muscle function.
Airway hyper-responsiveness associated with asthma is mediated by airway smooth muscle cells (SMCs) and has a complicated etiology involving increases in cell contraction and proliferation and the secretion of inflammatory mediators. Although these pathological changes are diverse, a common feature associated with their regulation is a change in intracellular Ca(2+) concentration ([Ca(2+)](i))....
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Regulation of intracellular Ca(2+) concentration ([Ca(2+)](i)) is a key factor in airway smooth muscle (ASM) tone. In vascular smooth muscle, specialized membrane microdomains (caveolae) expressing the scaffolding protein caveolin-1 are thought to facilitate cellular signal transduction. In human ASM cells, we tested the hypothesis that caveolae mediate Ca(2+) responses to agonist stimulation. ...
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IT HAS LONG BEEN KNOWN that release of intracellular stored Ca [presumably in the sarcoplasmic reticulum (SR)] plays a major role in initiating contraction in airway smooth muscle (ASM) from a variety of species (6) including human (17). Therefore, the issue of how extracellular calcium ions enter the cell to refill the SR is of particular importance to better understand Ca homeostasis in ASM, ...
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ژورنال
عنوان ژورنال: Pulmonary Pharmacology & Therapeutics
سال: 2009
ISSN: 1094-5539
DOI: 10.1016/j.pupt.2008.09.006